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Title   악성 선낭암에서 병리학적 등급이 예후에 미치는 영향 ( The Influence of Pathologic Grade on Adenoid Cystic Carcinoma )
Publicationinfo   1992 Jan; 024(04): 516-524.
Key_word   Adenoid cyctic carcinoma, Pathologic grade
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Abstract   Adenoid Cystic Carcinoma(ACC) is a relatively infrequent carcinoma, which grows slowly in- vades locally to nerves and bones. In order to ascertain the difference of prognosis and to predict the clinical prognosis in according to the patholgic grade at diagnosis, we followed up and studied 38 casee of ACC from Jan. 198l since Dec. 1990 in Severance hospital and Yonsei Cancer Center. Sixteen cases which were operated or diagnostically biopsied were patholo#gically reviewed in 38 cases of ACC. We performed the pathologic review of the 16 cases in according to degree of solid component, mitosis, or cellular atypia. Patients without solid pattern showed zero of DOD (died of disease), 3 of NED(no evidence of disease), and 3 of NED(no evidence of disease), and 3 of LWD(living with disease). Patients with solid pattern showed 4 of DOD, 2 of NED, and 4 of LWD. 10 year survival rate of patient with solid pattern was 64% which showed a tendency to be lower than that of patients without solid pattern(100% )(p=0.53). 5year survival rate of patients with mitosis was 66.2% which showed a tendency to be lower than that of patients with- out mitosis(100%)(p=0.37). 10 year survival rate was somewhat higher in patients with stage I & II than stage III 4 IV. In evaluation of solid pattern in according to the degree of mitosis and cellular atypia, we noticed that the more solid pattern, the more mitosis and cellular atypia. We got the tendency of influence of pathologic grade on ACC without statistical signif icance, because of small number of patients group and short period of study. And so further studies are warranted in clinical course with respect to pathologic grade, which would be the significant factor in prediction of the prognosis of ACC.
저 자   김주항(Joo Hang Kim),노재경(Jae Kyung Roh),김병수(Byung Soo Kim),고은희(Eun Hee Koh),정현철(Hyun Cheol Chung),최진혁(Jin Hyuk Choi),임호영(Ho Yeong Lim),김기용(Ki Yong Kim)